1.Postbiotics and Their Potential Applications in Early Life Nutrition and Beyond
2.Scavenger receptor for lipoteichoic acid is involved in the potent ability of Lactobacillus plantarum strain L-137 to stimulate production of interleukin-12p40.
3.Rational identification of diet-derived postbiotics for improving intestinal microbiota function
4.Probiotics for Gastrointestinal Conditions: A Summary of the Evidence
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炎性小体是由几种蛋白质组成的膜复合物,包括胱天蛋白酶1,胱天蛋白酶1在识别炎症信号后被蛋白质家族NLRP(Nod Like ReceptorProtein)激活。 迄今为止,已经描述了各种炎症小体,包括临床上与肥胖、胰岛素抵抗和轻度炎症有关的NLRP3(7)。 NLRP3半胱天冬酶1负责从无活性的前IL1β形成IL1β。抑制NLRP3是抗轻度炎症的优先选项。
Moore N et al. Adverse drug reactions and drug-drug interactions with over-the-counter NAIDs. 与非处方非甾体抗炎药的不良药物反应和药物相互作用 Ther Clin Risk Manag. 2015; 11:1061-75.
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Dower JI et al. Supplementation of the pure flavonoïds epicatechin and quercetin affects some biomarkers of endothelial dysfunction and inflammation in hypertensive adults: a randomized double-blind placebo controlled crossover trial补充纯黄酮表儿茶素和槲皮素会影响高血压成年人内皮功能障碍和炎症的某些生物标志物:一项随机双盲安慰剂对照交叉试验. J Nutr 2015; 145(7):1459-63.
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Bollmann F et al. Resveratrol post-transcriptionally regulates pro-inflammatory gene expression via regulation of KSRP RNA binding activity. 白藜芦醇在转录后通过调节KSRP RNA结合活性来调节促炎基因的表达 Nucleic acids Res. 2014; 40(20):12555-69.
Chang YP et al. Resveratrol inhibits NLRP3 inflammasome activation by preserving mitochondrial integrity and augmenting autophagy. 白藜芦醇通过保持线粒体完整性并增强自噬来抑制NLRP3炎性体激活 J Cell Physiol. 2015; 230(7):1567-79.
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Sengupta K el al. A double blind, randomized placebo controlled study of the efficacy and safety of 5-loxin for treatment of osteoarthritis of the knee. 5-loxin治疗膝盖骨关节炎的有效性和安全性的双盲随机安慰剂对照研究。Arthritis Res Ther. 2008; 10(4):R85.
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Mattmiller SA et al.Regulation of inflammation by selenium and selenoproteins: impact on eicosanoid biosynthesis. 硒和硒蛋白对炎症的调节:对类花生酸生物合成的影响。 J Nutr Sci. 2013; 2:e28.
Bonaventura P et al. Zinc and its role in immunity and inflammation. 锌及其在免疫和炎症中的作用 Autoimmun Rev. 2015; 14(4):277-85.
Prasad AS. Zinc is an antioxidant and anti-inflammatory agent: its role in human health. 锌作为抗氧化剂和消炎剂在人类健康中的作用 Front Nutr. 2014.
图5:微营养素对碳水化合物稳态的作用方式 (selon Hanhineva K et al. Int J Mol Sci 2010; 11(4):1365-1402)
图6:微量营养素,代谢综合症和2型糖尿病
图7:2型糖尿病的微营养素和并发症
图8:对胰岛素抵抗具有活性的微量营养素:汇总表。
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